Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Santa Cruz de la Sierra (34% of total searches to Bolivia). The next most popular destinations are La Paz (33%) and Uyuni (20%). Searches for hotels in Tupiza (14%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Bolivia is La Paz. Potosí and Santa Cruz are also very popular.