Welcome to the Holiday Inn Express Hotel & Suites Las Cruces. Enjoy a relaxing stay in our beautiful Las Cruces Holiday Inn Express near New Mexico State University (NMSU) and just a few minutes from historic Old Mesilla. Families enjoy this Southern New Mexico hotel because of our great location near New Mexico State University and because we are conveniently located just off I-10 and I-25 with easy access to nearby Las Cruces attractions. These attractions include Historic Old Mesilla the New Mexico Farm & Ranch Heritage Museum NMSU Pan American Center White Sands National Monument and the Las Cruces Farmers & Crafts Market. Leisure travelers can shop at nearby historic Old Mesilla Plaza featuring over 40 Southwestern craft shops. Lodging in Las Cruces puts you in the center of the Old West's history. Why settle for cheap lodging in Las Cruces NM when you can enjoy our comfortable and smoke free hotel near Old Mesilla? Government travelers will appreciate our close location to New Mexico State University NASA White Sands Testing Facility and US Army Reserve Center as well as free wired and wireless HSIA. Our Southern New Mexico hotel provides a complimentary hot Express Start breakfast bar a well-equipped 24-hour fitness center and an indoor heated pool with and spa. Book your reservations now and take advantage of our great Las Cruces hotel deals and rates for your next stay in New Mexico.