MDE - SCL

Find cheap flights from Medellín to Santiago – Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 20% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Direct flights
4 days a week
Mon, Thu, Fri, Sun
You can fly direct with JetSMART. Average duration is 6h 10m
Direct flights
Direct flights
+1
+1
Direct flights
Direct flights
+1
Avoid delays
JetSMART
Most punctual • 85% on-time
Morning flights
Best time • Fewest delays
Insights
Insights
Insights
Insights
When to book
7 weeks
in advance
Our data shows that travellers who book at least 7 weeks in advance save around 19% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
April
Cheapest • 8% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches hundreds of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Medellín to Santiago (MDE-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medellín to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medellín to Santiago

Multiple Airlines Logo
MDE
-
SCL
7118 kmmulti-stop
Multiple Airlines Logo
SCL
-
MDE
7118 kmmulti-stop
Multiple Airlines
Booking Insights

KAYAK's insights & trends for Medellín to Santiago flights

Get data-powered insights and trends into flights from Medellín to Santiago to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Medellín Jose Maria Cordova Intl Airport to Santiago is April, where tickets cost C$ 526 (return) on average. On the other hand, the most expensive months are February and July, where the average cost of round-trip tickets is C$ 677 and C$ 598 respectively.

How far in advance should I book a flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Medellín Jose Maria Cordova Intl Airport to Santiago, you should book around 7 weeks before departure, which saves you about 19% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 16 weeks before departure.

Find deals
Expert advice

Expert advice for your flight from Medellín to Santiago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Mark Chesnut

Mark Chesnut

Expert on Avianca

Mark Chesnut is a travel writer and public speaker with more than 30 years of experience. The 2019 winner of the NLGJA Excellence in Travel Writing Award, Mark is the author of the book “Prepare for Departure” and has covered air travel for multiple top consumer and trade media outlets.

Read more
Daniel Scheffler

Daniel Scheffler

Expert on JetSMART

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Read more

Good to know

Low season

April
Best time to beat the crowds (9% less expensive on average)
Most popular time to fly and prices are also 3% lower on average.

When to book flights from Medellín to Santiago

Are your dates flexible? Find out the best times to travel from Medellín to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Medellín to Santiago flights

  • How many flights are there between Medellín Jose Maria Cordova Intl Airport and Santiago per day?

    There is a maximum of 1 nonstop flight a day that takes off from Medellín Jose Maria Cordova Intl Airport and lands in Santiago, with an average flight time of 6h 10m. The most common departure time is 4:00 p.m. and most flights take off in the afternoon. Each week, there are 4 flights.

  • Which aircraft models fly most regularly from Medellín to Santiago?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Medellín to Santiago flight route.

  • On which days can I fly direct from Medellín to Santiago?

    You can catch a direct flight from Medellín to Santiago on Monday, Thursday, Friday, and Sunday.

  • How does KAYAK find such low prices on flights from Medellín to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medellín to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medellín to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Medellín is likely to change within 7 days, so travellers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medellín to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Medellín with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medellín to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Medellín up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Medellín Jose Maria Cordova Intl Airport to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for C$ 662 or less one-way.

Prefer to fly direct from Medellín to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez

Monday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more nonstop flights

Direct returns

Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

See more nonstop flights

Reviews of the top airline flying from Medellín to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Medellín to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medellín to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
LATAM AirlinesOverall score based on 1967 reviews
8.0Crew
7.0Entertainment
6.7Food
7.5Boarding
7.3Comfort
Airline reviews

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

10.0 ExcellentSarah, Jan 2026
ANF - SCL
Read more LATAM Airlines reviews

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

I liked everything, this was classed as premium economy but it was much better than Lufthansas business class. Lovely staff, comfortable plane and an excellent seat arrangement. A very pleasant surprise.

The crew was amazing. The best in the last times. Great group of people.

I do not read or speak in Spanish. Only English. When asking for help, the people spoke quickly in English and pointed a lot. I wish they would’ve spoken a little slower for me to understand. There was much confusion and hurried in their message and I was unclear as to where to go

It’s been some time since I saw the plane and the cabin that old and worn out.

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

Terrible They charged me 157$ for excess baggage even though my bags were within the normally accepted limits Flight was late. Service was poor. The snacks were really bad

Everything you need to know for your flight from Medellín to Santiago

Information on your arrival and departure airports

Medellín (MDE)
Santiago (SCL)