MDE - SCL

Find cheap flights from Medellín to Santiago

1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medellín to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medellín to Santiago, as well as popular online travel agencies
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Everything you should know

Advice from real travellers
AI-powered summary based on content written by travel experts. AI can make mistakes.
Avianca's Classic fare includes a carry-on and checked bag.
JetSMART's FlySMART fare only includes a small handbag.
Expert advice
Expert advice
Expert advice
Expert advice
Direct flights
4 days a week
Mon, Thu, Fri, Sun
You can fly direct with JetSMART. Average duration is 6h 10m
Direct flights
Direct flights
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Direct flights
Direct flights
+1
Avoid delays
Most punctual • 85% on-time
Best time • Fewest delays
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travellers who book at least 11 weeks in advance save around 18% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 6% price drop
Most popular
Good to know
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KAYAK searches hundreds of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Medellín to Santiago (MDE-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medellín to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medellín to Santiago

Multiple Airlines Logo
MDE
-
SCL
7118 kmmulti-stop
Multiple Airlines Logo
SCL
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MDE
7118 kmmulti-stop
Multiple Airlines
Booking Insights

KAYAK's insights & trends for Medellín to Santiago flights

Get data-powered insights and trends into flights from Medellín to Santiago to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Medellín Jose Maria Cordova Intl Airport to Santiago is April, where tickets cost C$ 524 (return) on average. On the other hand, the most expensive months are February and July, where the average cost of round-trip tickets is C$ 659 and C$ 566 respectively.

How far in advance should I book a flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Medellín Jose Maria Cordova Intl Airport to Santiago, you should book around 11 weeks before departure, which saves you about 18% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 21 weeks before departure.

Expert advice

Expert advice for your flight from Medellín to Santiago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Mark Chesnut

Mark Chesnut

Expert on Avianca

Mark Chesnut is a travel writer and public speaker with more than 30 years of experience. The 2019 winner of the NLGJA Excellence in Travel Writing Award, Mark is the author of the book “Prepare for Departure” and has covered air travel for multiple top consumer and trade media outlets.

Daniel Scheffler

Daniel Scheffler

Expert on JetSMART

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Good to know

Low seasonApril
Best time to beat the crowds (7% less expensive on average)
Most popular time to fly and prices are also 4% lower on average.

When to book flights from Medellín to Santiago

Are your dates flexible? Find out the best times to travel from Medellín to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Medellín to Santiago flights

  • Which aircraft models fly most regularly from Medellín to Santiago?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Medellín to Santiago flight route.

  • On which days can I fly direct from Medellín to Santiago?

    You can catch a direct flight from Medellín to Santiago on Monday, Thursday, Friday, and Sunday.

  • How does KAYAK find such low prices on flights from Medellín to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medellín to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medellín to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Medellín is likely to change within 7 days, so travellers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medellín to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Medellín with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medellín to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Medellín up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Medellín Jose Maria Cordova Intl Airport to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for C$ 649 or less one-way.

Prefer to fly direct from Medellín to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez

Monday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more nonstop flights

Direct returns

Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

See more nonstop flights

Reviews of the top airline flying from Medellín to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Medellín to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medellín to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
LATAM AirlinesOverall score based on 1920 reviews
7.5Boarding
7.0Entertainment
8.0Crew
6.7Food
7.3Comfort
Airline reviews

In flight from Miami to Anchorage, we were all on board ready to take off. Pilot decided to take on more fuel causing a delay. Once fueled, the pilot came back over the radio stating more delay due to VIP. These delays caused me to miss my connecting flight. I went to the Alaska Air counter for information. They flat out stated that it was ATCs fault that I missed my flight and booked me a flight the next day about 1300 . I believe if we had the fuel prior to getting on board we would not of been delayed and I would have taken off on time. Pilot was taken out of the equation. I think they should’ve taken responsibility for their pilots decision to top off his aircraft instead of waiting til the last moment. Enough said…

2.0 MediocreAnonymous, May 2026
LIM - MIA
Read more LATAM Airlines reviews

In flight from Miami to Anchorage, we were all on board ready to take off. Pilot decided to take on more fuel causing a delay. Once fueled, the pilot came back over the radio stating more delay due to VIP. These delays caused me to miss my connecting flight. I went to the Alaska Air counter for information. They flat out stated that it was ATCs fault that I missed my flight and booked me a flight the next day about 1300 . I believe if we had the fuel prior to getting on board we would not of been delayed and I would have taken off on time. Pilot was taken out of the equation. I think they should’ve taken responsibility for their pilots decision to top off his aircraft instead of waiting til the last moment. Enough said…

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Nothing I like, I missed this connection b/c of an earlier flight delay. I had to stay one more night and I paid out my own pocket. LATAM failed to send me to a safe and decent hotel.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Everything you need to know for your flight from Medellín to Santiago

Information on your arrival and departure airports