PTY - SDQ

Find cheap flights from Panama City to Santo Domingo – Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Direct flights
Every day
You can fly direct with Copa Airlines. Average duration is 2h 30m
Direct flights
Direct flights
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+1
Direct flights
Direct flights
+1
Avoid delays
Copa Airlines
Most punctual • 96% on-time
Night flights
Best time • Fewest delays
Insights
Insights
Insights
Insights
When to book
3 weeks
in advance
Our data shows that travellers who book at least 3 weeks in advance save around 31% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
September
Cheapest • 7% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
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KAYAK searches hundreds of sites at once to find you the best travel deals.
We hope you love your trip to Santo Domingo!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to Santo Domingo (PTY-SDQ)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Santo Domingo that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Santo Domingo

Multiple Airlines Logo
PTY
-
SDQ
2375 kmmulti-stop
Multiple Airlines Logo
SDQ
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PTY
2375 kmmulti-stop
Multiple Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Santo Domingo flights

Get data-powered insights and trends into flights from Panama City to Santo Domingo to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Santo Domingo?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Santo Domingo, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Santo Domingo is September, where tickets cost C$ 633 (return) on average. On the other hand, the most expensive months are July and May, where the average cost of round-trip tickets is C$ 765 and C$ 744 respectively.

Can I save money by flying with a layover from Panama City to Santo Domingo?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of C$ 652, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Panama City to Santo Domingo?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Panama City to Santo Domingo, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Panama City to Santo Domingo, you should book around 3 weeks before departure, which saves you about 31% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 9 weeks before departure.

Find deals

Good to know

Low season

April
Best time to beat the crowds but there is an average 9% increase in price.
Most popular time to fly and prices are also 2% lower on average.

When to book flights from Panama City to Santo Domingo

Are your dates flexible? Find out the best times to travel from Panama City to Santo Domingo based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Santo Domingo

  • Which aircraft models fly most regularly from Panama City to Santo Domingo?

    The Boeing 737-800 is the aircraft model that flies most regularly on the Panama City to Santo Domingo flight route.

  • Which airline alliances offer flights from Panama City to Santo Domingo?

    Star Alliance is the only airline alliance operating flights between Panama City and Santo Domingo.

  • On which days can I fly direct from Panama City to Santo Domingo?

    There are direct flights from Panama City to Santo Domingo on a daily basis.

  • Which is the best airline for flights from Panama City to Santo Domingo, Copa Airlines or Avianca?

    The two airlines most popular with KAYAK users for flights from Panama City to Santo Domingo are Copa Airlines and Avianca. With an average price for the route of C$ 667 and an overall rating of 7.6, Copa Airlines is the most popular choice. Avianca is also a great choice for the route, with an average price of C$ 637 and an overall rating of 6.5.

  • How does KAYAK find such low prices on flights from Panama City to Santo Domingo?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Santo Domingo.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Santo Domingo?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santo Domingo from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Santo Domingo?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santo Domingo with an airline and back to Panama City with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Santo Domingo?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santo Domingo from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Panama City to Santo Domingo?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Panama City Tocumen Intl to Santo Domingo Las Americas.
Find which airlines fly direct from Panama City Tocumen Intl Airport to Santo Domingo Las Americas Airport, which days they fly and book direct flights.

Direct departures

Panama City Tocumen Intl to Santo Domingo Las Americas

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines

Copa Airlines

Wednesday

Copa Airlines

Copa Airlines

Thursday

Copa Airlines

Copa Airlines

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more nonstop flights

Direct returns

Santo Domingo Las Americas to Panama City Tocumen Intl

Monday

Copa Airlines

Copa Airlines

Tuesday

Copa Airlines

Copa Airlines

Wednesday

Copa Airlines

Copa Airlines

Thursday

Copa Airlines

Copa Airlines

Friday

Copa Airlines

Copa Airlines

Saturday

Copa Airlines

Copa Airlines

Sunday

Copa Airlines

Copa Airlines

See more nonstop flights

Reviews of the top airlines flying from Panama City to Santo Domingo

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Santo Domingo. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Santo Domingo? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1562 reviews
7.8Boarding
6.8Entertainment
7.4Comfort
8.1Crew
6.9Food
Airline reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

4.0 OkayAnonymous, Jun 2026
PTY - AUS
Read more Copa Airlines reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

Orderly boarding, priority for platinum members, courtesy drinks from business class even when we were seating in economy.

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

Copa staff at PTY and one particular crew member were unhelpful & rude.

A lot things happened in this trip.The fly should be less stress.

Horrible. No TV or any type of entertainment on board. Passwnger listening to/watching stuff on their own phone with no headphones making it noise and uncomfortable for everyone else, little/tiny food portions, old seats, useless wifi (cant access anything). Horrible exlerience especially it was a lomg distance flight with kids.

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

Some of the Air hostesses are not that friendly. Need improvement

The airline did not allow enough time for the Columbia checkpoint

This was my first time flying with you guys and my very last! This was the most horrible experience!!! There was not even tv in the plane! How cheap can this airline be!!! I paid so much for my suitcase!!! I would never fly with this airline again! The crew are very rude!

The usb plugs for charging your phone didn’t work, the seats were coarse and hard. Not very comfortable. No inflight WiFi

Not what it used to be. The sale of food makes them look greedy!

Kiwi is the worst, I couldn’t flight for work, Kiwi kept 100% of my money (they didn’t even return the taxes) I will not buy with kiwi again

delayed rio bogota - delayed for 4 hs from bog to mia. the seat are too small

This is the Spirit of Latino travel. And don’t even get me started on customer service.

I flew with my service dog unfortunately they didn’t allow it to flight on the canine, but ok, the only problem was that when I arrived to Quito it took 1 hour to deliver my dog, they were supposed to deliver it the moment we get off the airplane.

Flight departure late. Got late in Colombia making us take a different flight next day. Avianca airport crew messed up my ticket so when a I got in Brazil I didn’t have a ticket for my destination. Had to buy a new ticket out of my pocket.

I paid extra for seats up front, I expected unless the beverages wold be included,

Everything you need to know for your flight from Panama City to Santo Domingo

Information on your arrival and departure airports

Panama City (PTY)
Santo Domingo (SDQ)